Gilead Sciences, Inc.
Senior Associate Scientist, Oncology Research
Gilead Sciences, Inc., Foster City, California, United States, 94420
Senior Associate Scientist, Oncology Research
Job Description
At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.Gilead Sciences (Foster City, CA) is seeking a talented and highly motivated scientist to join our oncology research group. Our collaborative and interdisciplinary research team utilizes state-of-the-art technologies and innovative methodologies to advance medicines into the clinic. The successful candidate is expected to contribute to the discovery, research, and development of novel therapeutic agents to address unmet medical needs of cancer patients. S/he will have opportunities for career growth through acquisition of new skills, experiences, and professional relationships in a fast-paced and resource-rich environment.Key ResponsibilitiesIndependently plan, execute, analyze, troubleshoot, and interpret
in vitro
and
ex vivo
experiments that support non-routine research activities and projects goals.Proactively evaluate new technologies and develop new assays to accelerate early-stage discovery activities and/or enhance our understanding of disease mechanisms.Support multiple projects simultaneously and work cross-functionally with colleagues in the oncology, chemistry, protein engineering, pathobiology, DMPK, biomarker and clinical groups.Present research findings and recommendations to senior staff and contribute to preparation of research reports, manuscripts, INDs, and patent filings.Provide coaching and training to junior and/or less experienced colleagues in solving technical and scientific problems.EducationMaster's degree and 8+ years of experience or Bachelor's degree and 10+ years of experience in cell biology, molecular biology, or biochemistry in biotechnology or pharmaceutical industry.Required experience and skillsExtensive experience in cancer cell biology, target identification/validation in oncology or immuno-oncology.Experience working with small molecules.Extensive experience in general molecular and cell biology methods including primary human and mouse cell culture and basic flow cytometry.High proficiency in techniques evaluating cell signaling (e.g. western blot, ELISA, MSD, immunofluorescence, reporter-based assays) and proliferation/survival using small-molecules and biologics.Proficiency in methods evaluating gene expression (e.g. RT-qPCR, Nanostring and others).Experience with methods to perturb gene function (e.g. RNAi, CRISPR, overexpression) and to deliver constructs (e.g. transfection, electroporation, lentiviral transduction).Experience with quantitative cellular assays.Attention to detail with excellent organizational and record keeping skills.Excellent communication and interpersonal skills.Preferred skillsExpertise in cell cycle analysis and high content imaging.A strong record of achievements, contributions to drug discovery programs and publications.
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Job Description
At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.Gilead Sciences (Foster City, CA) is seeking a talented and highly motivated scientist to join our oncology research group. Our collaborative and interdisciplinary research team utilizes state-of-the-art technologies and innovative methodologies to advance medicines into the clinic. The successful candidate is expected to contribute to the discovery, research, and development of novel therapeutic agents to address unmet medical needs of cancer patients. S/he will have opportunities for career growth through acquisition of new skills, experiences, and professional relationships in a fast-paced and resource-rich environment.Key ResponsibilitiesIndependently plan, execute, analyze, troubleshoot, and interpret
in vitro
and
ex vivo
experiments that support non-routine research activities and projects goals.Proactively evaluate new technologies and develop new assays to accelerate early-stage discovery activities and/or enhance our understanding of disease mechanisms.Support multiple projects simultaneously and work cross-functionally with colleagues in the oncology, chemistry, protein engineering, pathobiology, DMPK, biomarker and clinical groups.Present research findings and recommendations to senior staff and contribute to preparation of research reports, manuscripts, INDs, and patent filings.Provide coaching and training to junior and/or less experienced colleagues in solving technical and scientific problems.EducationMaster's degree and 8+ years of experience or Bachelor's degree and 10+ years of experience in cell biology, molecular biology, or biochemistry in biotechnology or pharmaceutical industry.Required experience and skillsExtensive experience in cancer cell biology, target identification/validation in oncology or immuno-oncology.Experience working with small molecules.Extensive experience in general molecular and cell biology methods including primary human and mouse cell culture and basic flow cytometry.High proficiency in techniques evaluating cell signaling (e.g. western blot, ELISA, MSD, immunofluorescence, reporter-based assays) and proliferation/survival using small-molecules and biologics.Proficiency in methods evaluating gene expression (e.g. RT-qPCR, Nanostring and others).Experience with methods to perturb gene function (e.g. RNAi, CRISPR, overexpression) and to deliver constructs (e.g. transfection, electroporation, lentiviral transduction).Experience with quantitative cellular assays.Attention to detail with excellent organizational and record keeping skills.Excellent communication and interpersonal skills.Preferred skillsExpertise in cell cycle analysis and high content imaging.A strong record of achievements, contributions to drug discovery programs and publications.
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