Ashvattha Therapeutics, Inc.
Sr. Scientist I/II (Translational)
Ashvattha Therapeutics, Inc., Redwood City, California, United States, 94061
Ashvattha Therapeutics, a clinical stage biopharmaceutical company located in Redwood City, is seeking a Sr. Scientist/II, Translational. Ashvattha Therapeutics is focused on developing novel nanomedicines, HD therapeutics (HDTs), to treat unmet medical needs in ophthalmology, neurology, inflammatory diseases, and neuro-oncology. Our HD platform builds therapeutics that are selectively taken up only by inflamed tissues, allowing us to treat diseases with unprecedented precision.
The Position
This person will be responsible for the design and interpretation of in vivo experiments executed at CROs supporting both mechanism of action pharmacology studies as well as nonclinical safety/PK studies. They will be the lead representative managing the CROs to ensure execution of robust study designs and deliver clear, rigorous, interpretation of the data. This person will also design and implement in-house analyses of animal tissues following the conclusion of in vivo studies, with a heavy emphasis on histological readouts (immunofluorescence/immunohistochemistry). Additional analyses such as plasma biomarkers and gene expression may be executed either in-house or outsourced to CROs. The candidate will also have a good understanding of PKPD relationships and contribute towards early biomarker discovery and development. This person will be responsible for managing and training a research associate to perform the tasks above, and may be required to execute complex experimental protocols to establish new assays and troubleshoot issues prior to standardization of assays. Tissues and disease indications may span neurology (brain/spinal cord), oncology, ophthalmology, or other peripheral inflammatory diseases.
Who You Are
Ph.D. degree in Biology, Biochemistry, Pharmacology, Neuroscience, or related discipline.
At least 5 years of relevant laboratory experience post PhD, minimum 2 years experience in the biopharmaceutical industry.
The candidate must be an expert in standard in vivo assays and analyses such as IHC, FACS/flow cytometry, qPCR, ELISAs, and Western blots.
The candidate must also have experience working with image analysis software to independently analyze histological data, and be comfortable learning new technical microscopy equipment.
The candidate should also have prior experience managing or mentoring a research associate and a proven track record of scientific success.
They should exhibit exemplary written and verbal communication skills along with interpersonal skills to work collaboratively within and across functions at a small company and a fast paced environment.
Independent, problem-solving, and troubleshooting skills
Technical writing experience such as protocols and reports
Must be able to work on site, full time at our laboratories.
What We Can Offer You
This is a unique opportunity to join a team focused on the development of a new class of precision medicines that selectively treat diseased cells in regions of inflammation. By making precision medicine even more precise, our nanomedicine technology has the potential to change the standard of care across ophthalmology, neurology, inflammatory diseases and neuro-oncology. You will have the opportunity to learn new skills and gain a better understanding of the cutting-edge technology.
We have a comprehensive total compensation package including fully paid medical, dental and vision benefits for you and your family. We want our employees to become shareholders and offer new hire stock options. The company also offers participation in the annual bonus program. The salary range for candidates located in the Bay Area is in the range of $120,000 - $160,000 depending on degree, years of experience and skill sets.
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The Position
This person will be responsible for the design and interpretation of in vivo experiments executed at CROs supporting both mechanism of action pharmacology studies as well as nonclinical safety/PK studies. They will be the lead representative managing the CROs to ensure execution of robust study designs and deliver clear, rigorous, interpretation of the data. This person will also design and implement in-house analyses of animal tissues following the conclusion of in vivo studies, with a heavy emphasis on histological readouts (immunofluorescence/immunohistochemistry). Additional analyses such as plasma biomarkers and gene expression may be executed either in-house or outsourced to CROs. The candidate will also have a good understanding of PKPD relationships and contribute towards early biomarker discovery and development. This person will be responsible for managing and training a research associate to perform the tasks above, and may be required to execute complex experimental protocols to establish new assays and troubleshoot issues prior to standardization of assays. Tissues and disease indications may span neurology (brain/spinal cord), oncology, ophthalmology, or other peripheral inflammatory diseases.
Who You Are
Ph.D. degree in Biology, Biochemistry, Pharmacology, Neuroscience, or related discipline.
At least 5 years of relevant laboratory experience post PhD, minimum 2 years experience in the biopharmaceutical industry.
The candidate must be an expert in standard in vivo assays and analyses such as IHC, FACS/flow cytometry, qPCR, ELISAs, and Western blots.
The candidate must also have experience working with image analysis software to independently analyze histological data, and be comfortable learning new technical microscopy equipment.
The candidate should also have prior experience managing or mentoring a research associate and a proven track record of scientific success.
They should exhibit exemplary written and verbal communication skills along with interpersonal skills to work collaboratively within and across functions at a small company and a fast paced environment.
Independent, problem-solving, and troubleshooting skills
Technical writing experience such as protocols and reports
Must be able to work on site, full time at our laboratories.
What We Can Offer You
This is a unique opportunity to join a team focused on the development of a new class of precision medicines that selectively treat diseased cells in regions of inflammation. By making precision medicine even more precise, our nanomedicine technology has the potential to change the standard of care across ophthalmology, neurology, inflammatory diseases and neuro-oncology. You will have the opportunity to learn new skills and gain a better understanding of the cutting-edge technology.
We have a comprehensive total compensation package including fully paid medical, dental and vision benefits for you and your family. We want our employees to become shareholders and offer new hire stock options. The company also offers participation in the annual bonus program. The salary range for candidates located in the Bay Area is in the range of $120,000 - $160,000 depending on degree, years of experience and skill sets.
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