Principal Scientist, Medicinal Chemistry

What if …you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.The Company :Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.Position SummaryQuotient Tx is seeking a talented and highly motivated Principal Scientist, Medicinal Chemistry with relevant drug discovery experience to join our team. This is an exciting opportunity to design and execute medicinal chemistry strategies that will support biology validation and drug discovery from hit finding to lead generation, lead optimization and candidate selection. The successful candidate will work closely with Quotient’s Leadership Team and scientists to rapidly advance drug discovery programs to IND and early clinical studies. They will be comfortable working in and contributing to a highly dynamic and cross-functional team environment. The ideal candidate must be independent, open-minded, goal-oriented, have excellent communication skills and work in a fast-paced entrepreneurial environment.Key ResponsibilitiesDiscover and advance novel chemical entities (small molecules, protacs, molecular glues) into clinical developmentDefine, implement, and execute on medicinal chemistry strategies from hit ID to lead generation, lead optimization and candidate selectionProvide strategic, scientific, and managerial leadership to external CRO med chem teamsServe as project and chemistry lead for drug discovery programsCollaborate with the IP team to create and execute strategy to establish, protect and expand intellectual propertyCommunicate, collaborate, and coordinate effectively within cross-functional teamsEffectively present and communicate research findings at internal meetings and external scientific conferencesJob QualificationsPh.D. in Organic Chemistry or Medicinal Chemistry with a minimum of 10+ years of relevant drug discovery experience in the biotech/pharmaceutical industryExperienced in all aspects of medicinal chemistry including use of tool/probe compounds, hit ID and follow-up, hit-to-lead chemistry, and lead optimization to candidate selectionBroad background in all aspects of drug discovery, including SBDD, physicochemical property-driven optimization (MPO) and computational chemistryWorking knowledge of structural biology, ADME/PK, in vitro assays, and in vivo pharmacologyExperience in managing and building strong relationships with chemistry CROsDemonstrated success in leading medicinal chemistry and projects teams to deliver high quality compounds into developmentExperience in oligonucleotide drug discovery is a plusTrack record of delivering on project and company goalsAbility to accommodate to rapidly changing priorities and deadlinesExcellent communication and project leadership skills and ability to work effectively in a cross-functional team settingProven track record for striving for a high level of innovation and scientific excellenceLocation:

Cambridge, MAAbout Flagship:Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at

www.flagshippioneering.com .Flagship Pioneering and our ecosystem companies are

committed to equal employment opportunity

regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.Recruitment & Staffing Agencies:

Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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