Flagship Pioneering, Inc.
Principal Scientist, Discovery Biology
Flagship Pioneering, Inc., Cambridge, Massachusetts, us, 02140
Company Summary
What if…
you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?
Prologue Medicines is dedicated to transforming drug discovery by leveraging deep biological insights and cutting-edge scientific innovations. Our mission is to deliver breakthrough therapies that address critical unmet medical needs. As part of our dynamic and collaborative team, you will have the opportunity to impact human health on a global scale.
Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
Position Overview:
Prologue is seeking an experienced and highly motivated Principal Scientist with a proven track record of early discovery and characterization of novel biologics to join our team. The successful candidate will work closely with the team to establish innovative HT and multi-dimensional screening assays for the identification of novel molecules and the evaluation of their MoA, helping to drive our platform and therapeutic pipeline forward. They will also contribute to platform and project advancement through interfacing with matrix teams and managing deliverables related to Discovery campaigns.
Key Responsibilities:
Responsible for conducting significantly impactful research and experiments for Discovery biology and advancing the platform.
Influences the direction of scientific function and in turn guides Prologue's research strategy.
Design innovative screening assays promoting collaboration across scientific disciplines in a fast-paced, nimble organization.
Applies advanced scientific analytical expertise and judgement solving for significantly complex issues.
Stay scientifically current and contribute to the implementation of new technologies and advanced screening strategies.
Interface with the computational team to formulate strategy for target and hit identification.
Determines the feasibility of applying advanced scientific principles and techniques to scientific programs while ensuring alignment with company objectives.
Provides strategic leadership to target selection and validation and proposes novel screening strategies for complex and unique scientific outcomes to generate value for the platform.
Maintain a strong sense of teamwork, mentoring colleagues on the development and execution of biologics screening experiments.
Qualifications:
PhD in Immunology or a related discipline with a minimum of 12+ years relevant experience in industry required.
Prior experience in development of standard assays such as ELISA, cell-based reporter and pharmacological assays for biologic drugs is required.
Extensive experience in designing robust screening strategies which include statistical assay design, such as leveraging principles of Design of Experiment (DoE).
Evidence of creativity in establishing assays across a variety of biologic mechanisms.
Proven success in project management and team leadership.
Previous management experience/developing employees.
Excellent communication, attention to detail, documentation and technical writing skills.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies:
Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
#J-18808-Ljbffr
What if…
you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?
Prologue Medicines is dedicated to transforming drug discovery by leveraging deep biological insights and cutting-edge scientific innovations. Our mission is to deliver breakthrough therapies that address critical unmet medical needs. As part of our dynamic and collaborative team, you will have the opportunity to impact human health on a global scale.
Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
Position Overview:
Prologue is seeking an experienced and highly motivated Principal Scientist with a proven track record of early discovery and characterization of novel biologics to join our team. The successful candidate will work closely with the team to establish innovative HT and multi-dimensional screening assays for the identification of novel molecules and the evaluation of their MoA, helping to drive our platform and therapeutic pipeline forward. They will also contribute to platform and project advancement through interfacing with matrix teams and managing deliverables related to Discovery campaigns.
Key Responsibilities:
Responsible for conducting significantly impactful research and experiments for Discovery biology and advancing the platform.
Influences the direction of scientific function and in turn guides Prologue's research strategy.
Design innovative screening assays promoting collaboration across scientific disciplines in a fast-paced, nimble organization.
Applies advanced scientific analytical expertise and judgement solving for significantly complex issues.
Stay scientifically current and contribute to the implementation of new technologies and advanced screening strategies.
Interface with the computational team to formulate strategy for target and hit identification.
Determines the feasibility of applying advanced scientific principles and techniques to scientific programs while ensuring alignment with company objectives.
Provides strategic leadership to target selection and validation and proposes novel screening strategies for complex and unique scientific outcomes to generate value for the platform.
Maintain a strong sense of teamwork, mentoring colleagues on the development and execution of biologics screening experiments.
Qualifications:
PhD in Immunology or a related discipline with a minimum of 12+ years relevant experience in industry required.
Prior experience in development of standard assays such as ELISA, cell-based reporter and pharmacological assays for biologic drugs is required.
Extensive experience in designing robust screening strategies which include statistical assay design, such as leveraging principles of Design of Experiment (DoE).
Evidence of creativity in establishing assays across a variety of biologic mechanisms.
Proven success in project management and team leadership.
Previous management experience/developing employees.
Excellent communication, attention to detail, documentation and technical writing skills.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies:
Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
#J-18808-Ljbffr