Iambic Therapeutics, Inc.
Associate Director/Director Medicinal Chemistry
Iambic Therapeutics, Inc., San Diego, California, United States, 92189
Director or Associate Director, Medicinal ChemistryPOSITION
We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
EMPLOYMENT TYPE
Full-time. Location in San Diego.
KEY RESPONSIBILITIES
Lead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates.
Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis-driven design principles.
Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions.
Act as liaison between Iambic, CROs, and other external partners.
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities.
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules.
Communicate project updates clearly and effectively to the broader team and key stakeholders.
Work as a senior member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork.
PREFERRED QUALIFICATIONS
Ph.D. in Organic Chemistry and 8+ years of experience in Pharma/bio-tech drug discovery or Master's in Organic Chemistry and 12+ years of similar experience.
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents.
Ability to integrate multiple R&D disciplines into a successful strategic project plan.
Experience in leading projects and driving programs through the preclinical development process.
Experience working with computational chemists as part of project team in design of drug targets is required.
Strong interpersonal, communication, time management, and leadership skills.
Experience mentoring or leading junior chemists.
Creative problem solving and management of relationships with several stakeholders within and beyond the company.
ABOUT IAMBIC
Iambic is disrupting the therapeutics landscape with its cutting-edge generative AI drug discovery platform. We have assembled a world-class team that unites pioneering AI experts and seasoned drug hunters with strong track records of success in delivering clinically validated breakthrough treatments. The Iambic platform has been demonstrated to deliver high quality, differentiated drugs to clinic with unprecedented speed and across multiple target classes and mechanisms of action. We are focused on the advancement of our internal pipeline of clinical assets to address urgent unmet patient needs in oncology and other therapeutic areas.
MISSION & CORE VALUES
The culture and work at Iambic are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and unlimited vacation to our team. We are located in a brand-new state-of-the-art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
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We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
EMPLOYMENT TYPE
Full-time. Location in San Diego.
KEY RESPONSIBILITIES
Lead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates.
Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis-driven design principles.
Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions.
Act as liaison between Iambic, CROs, and other external partners.
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities.
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules.
Communicate project updates clearly and effectively to the broader team and key stakeholders.
Work as a senior member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork.
PREFERRED QUALIFICATIONS
Ph.D. in Organic Chemistry and 8+ years of experience in Pharma/bio-tech drug discovery or Master's in Organic Chemistry and 12+ years of similar experience.
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents.
Ability to integrate multiple R&D disciplines into a successful strategic project plan.
Experience in leading projects and driving programs through the preclinical development process.
Experience working with computational chemists as part of project team in design of drug targets is required.
Strong interpersonal, communication, time management, and leadership skills.
Experience mentoring or leading junior chemists.
Creative problem solving and management of relationships with several stakeholders within and beyond the company.
ABOUT IAMBIC
Iambic is disrupting the therapeutics landscape with its cutting-edge generative AI drug discovery platform. We have assembled a world-class team that unites pioneering AI experts and seasoned drug hunters with strong track records of success in delivering clinically validated breakthrough treatments. The Iambic platform has been demonstrated to deliver high quality, differentiated drugs to clinic with unprecedented speed and across multiple target classes and mechanisms of action. We are focused on the advancement of our internal pipeline of clinical assets to address urgent unmet patient needs in oncology and other therapeutic areas.
MISSION & CORE VALUES
The culture and work at Iambic are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and unlimited vacation to our team. We are located in a brand-new state-of-the-art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
#J-18808-Ljbffr