Novartis Farmacéutica
Senior Scientist II/Principal Scientist I Biotransformation, PK Sciences
Novartis Farmacéutica, Cambridge, Massachusetts, us, 02140
Job ID: REQ-10023641Date: Oct 02, 2024Location: Cambridge, MA, USASummary
This position is located in Cambridge, MA. The Pharmacokinetic Sciences (PKS) Department within the Novartis Biomedical Research Division (BR) is looking for a laboratory-based biotransformation scientist with experience in metabolite identification and profiling to join their global biotransformation team with groups in Europe and North America.As a biotransformation scientist, you will develop state-of-the-art analytical methodologies using ultra/high performance liquid chromatography (U/HPLC) coupled with high resolution mass spectrometry (HRMS) to identify metabolites and elucidate biotransformation pathways from complex biologic matrices. This role will require familiarity with various in vitro enzymatic systems used in drug metabolism biotransformation studies as well as extraction procedures such as protein precipitation, liquid/liquid extraction (LLE), and solid phase extraction (SPE). Experience with the biotransformation of peptides, oligonucleotides, and/or intact proteins would be considered highly advantageous.About the Role
As the successful candidate, you will plan and execute fit-for-purpose experiments, maintain the laboratory environment/instruments, and support the development of new technologies. You will also be expected to interact with and present your findings in team meetings, document your findings in an electronic notebook, and prepare internal reports. Depending on the seniority of the successful candidate, you will represent the ADME line function in PKS sub-teams and project teams, collaborate in the preparation of external publications, and contribute to registration documents.Key Responsibilities:Design and execution of biotransformation studies to assess metabolic pathways and structural elucidation of metabolites.Organize and prepare experimental protocols and study reports with upload of results to a centralized database.Presentation of key findings to team members and/or other stakeholders.Support
in vitro
and
in vivo
discovery, pre-clinical, and clinical development biotransformation studies.Assure quality standard guidelines and safe work practices are applied while working in the laboratories.Minimum Requirements:Degree in Analytical/Medicinal Chemistry, Biochemistry, Biology, or Pharmaceutical Sciences, with knowledge of drug discovery/development.PhD with 0 years, MS with 3+ years, or BS with 8+ years of relevant experience.Hands-on experience in operation, maintenance, and troubleshooting of state-of-the-art high resolution mass spectrometers.Excellent oral and written communication skills.Careful attention to detail, exceptional organizational skills, and ability to multitask.Team player with ability to be flexible and adapt to a changing environment.Prior experience with small molecule metabolite identification, structural elucidation, and biotransformation studies.Familiarity with in vitro systems commonly used for drug metabolism studies (hepatocytes, homogenate, microsomes, S9 fraction, recombinant enzymes).Experience with intact protein, immunoprecipitation, peptide, and/or oligonucleotide analysis would be considered a bonus.This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.
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This position is located in Cambridge, MA. The Pharmacokinetic Sciences (PKS) Department within the Novartis Biomedical Research Division (BR) is looking for a laboratory-based biotransformation scientist with experience in metabolite identification and profiling to join their global biotransformation team with groups in Europe and North America.As a biotransformation scientist, you will develop state-of-the-art analytical methodologies using ultra/high performance liquid chromatography (U/HPLC) coupled with high resolution mass spectrometry (HRMS) to identify metabolites and elucidate biotransformation pathways from complex biologic matrices. This role will require familiarity with various in vitro enzymatic systems used in drug metabolism biotransformation studies as well as extraction procedures such as protein precipitation, liquid/liquid extraction (LLE), and solid phase extraction (SPE). Experience with the biotransformation of peptides, oligonucleotides, and/or intact proteins would be considered highly advantageous.About the Role
As the successful candidate, you will plan and execute fit-for-purpose experiments, maintain the laboratory environment/instruments, and support the development of new technologies. You will also be expected to interact with and present your findings in team meetings, document your findings in an electronic notebook, and prepare internal reports. Depending on the seniority of the successful candidate, you will represent the ADME line function in PKS sub-teams and project teams, collaborate in the preparation of external publications, and contribute to registration documents.Key Responsibilities:Design and execution of biotransformation studies to assess metabolic pathways and structural elucidation of metabolites.Organize and prepare experimental protocols and study reports with upload of results to a centralized database.Presentation of key findings to team members and/or other stakeholders.Support
in vitro
and
in vivo
discovery, pre-clinical, and clinical development biotransformation studies.Assure quality standard guidelines and safe work practices are applied while working in the laboratories.Minimum Requirements:Degree in Analytical/Medicinal Chemistry, Biochemistry, Biology, or Pharmaceutical Sciences, with knowledge of drug discovery/development.PhD with 0 years, MS with 3+ years, or BS with 8+ years of relevant experience.Hands-on experience in operation, maintenance, and troubleshooting of state-of-the-art high resolution mass spectrometers.Excellent oral and written communication skills.Careful attention to detail, exceptional organizational skills, and ability to multitask.Team player with ability to be flexible and adapt to a changing environment.Prior experience with small molecule metabolite identification, structural elucidation, and biotransformation studies.Familiarity with in vitro systems commonly used for drug metabolism studies (hepatocytes, homogenate, microsomes, S9 fraction, recombinant enzymes).Experience with intact protein, immunoprecipitation, peptide, and/or oligonucleotide analysis would be considered a bonus.This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.
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