Senior Scientist - Computational Materials Science

Why Patients Need YouPfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.What You Will AchieveAn essential component of Pfizer, our Pharmaceutical Sciences function supports Pfizer’s early to late-stage portfolio translating new chemical entities into commercial drug products. In your role as a member of the Pharmaceutical Sciences team, you will work in a team which integrates Chemistry and Manufacturing and Controls capabilities - work that encompasses state of the art active pharmaceutical ingredient synthesis and drug product design, as well as a cGMP manufacturing and clinical trials supply chain.As a Computational Materials Scientist, you will apply state-of-the-art computational chemistry and crystallographic tools to predict the solid-state and particle properties of Pfizer molecules to streamline experimental efforts and to design better medicines. This will enable Pfizer project teams to de-risk their programs and to move rapidly into clinical studies with the goal of commercialization. The role is highly collaborative, requiring extensive work on multi-disciplinary project teams. With this role there is also a significant opportunity to publish peer reviewed research and to develop novel computational methods, addressing gaps in our current knowledge and capabilities.How You Will Achieve ItApply state-of-the-art physics based computational approaches to predict the properties and performance across range of molecules (R05 and bR05).Conduct crystal structure prediction (CSP) calculations and free energy calculations for polymorph stability ranking.Utilize various physics/informatics (i.e. molecular simulations, density functional theory, H-bonding propensity analysis, full Interaction map) based computational tools for design and derisking of commercial solid form.Develop and apply physics/ML-AI based computational tools to investigate and understand the particle properties, surface and performance.Participate on multidisciplinary project teams and collaborate with colleagues to define and recommend follow up screening and characterization strategies to complement computational studies according to project timelines.Oversee the work of external partners conducting computational analyses and provide tactical guidance and critical analysis of their work.Solve scientific problems using contemporary solid state computational techniques.Lead the development of new scientific approaches and knowledge within the Material Sciences organization. This is an individual contributor role.QualificationsMust-HaveCandidate to have a PhD in Computational Chemistry, Physics, Materials Science or Engineering, or a closely-related discipline; OR a Master’s degree in these disciplines with 5-10 years of relevant experience in industry or academia. This is an individual contributor role.Strong coding skills in a scientific programming language (such as C/C++, Python, Perl) with demonstrated evidence of coding expertise and data analysis.Competency in UNIX/Linux and HPC environments for submission and monitoring of jobs.Nice-to-HaveExperience with computational chemistry software (GROMACS, Gaussian, GAMESS-US, cp2k, quantum espresso and VASP) and the CCDC tools preferred.Knowledgeable of fundamental physical chemistry and materials science concepts such as thermodynamics, solvation, crystallography, symmetry, nucleation and crystal growth — either through coursework or experience.Strong analytical and mathematical skills (geometry, algebra, statistics, differential calculus).

Relocation support availableWork Location Assignment: On PremiseThe annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.Relocation assistance may be available based on business needs and/or eligibility.Sunshine ActPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.EEO & Employment EligibilityPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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