Moffitt Cancer Center Partnership
Molecular Oncology Postdoctoral Fellow
Moffitt Cancer Center Partnership, Tampa, Florida, us, 33646
Molecular Oncology Postdoctoral Fellow
Location: Tampa, FLDepartment: Molecular OncologySchedule: Full Time - Day Shift - variesAt Moffitt Cancer Center, we strive to be the leader in understanding the complexity of cancer and applying these insights to contribute to the prevention and cure of cancer. Our diverse team of over 9,000 is dedicated to serving our patients and creating a workspace where every individual is recognized and appreciated. For this reason, Moffitt has been recognized on the 2023 Forbes list of America’s Best Large Employers and America’s Best Employers for Women. Additionally, Moffitt is proud to have earned the prestigious Magnet designation in recognition of its nursing excellence.SummaryMolecular Oncology Postdoctoral Fellow in the lab of Dr. Jiandong ChenThe research interest of the lab is to study the structures, regulation, and therapeutic targeting of the p53 tumor suppressor pathway for cancer treatment. Ongoing work involves the development of novel PROTACs, targeting of temperature-sensitive mutant p53, transcription potential of mutant p53, and MDMX regulation of Wnt signaling. Link to publications from Dr. Chen’s lab:The lab has significant expertise and provides mentorship in the areas of p53/MDM2/MDMX phosphorylation signaling, ubiquitination, transcriptional regulation, and drug discovery using biochemical/cellular assays and mouse tumor models.Extensive collaborations with chemists and structural biologists working in drug discovery, providing a rich environment for training and career development.Moffitt integrates excellent patient care with cutting-edge clinical and basic research.Outstanding mentorship from expert faculty with wide-ranging funded research programs including T32 Training Grants.You will be encouraged and supported to apply for training grants.The Ideal Candidate:Strong background in biochemistry and molecular biology.Experience with mouse tumor xenograft models or genetically modified mouse models.Experience in the analysis of novel drug activity and mechanisms.Competent in cell culture, protein analysis, CRISPR, and recombinant DNA techniques.Recent PhD graduate in biochemistry or molecular biology.Responsibilities:Plans and performs experiments directed towards answering specific scientific questions with limited supervision under the general guidance of the Investigator.Interacts closely with the Investigator and other researchers within the Investigator laboratory and conducts relevant background research including literature searches and reviews.Credentials and Qualifications:MD or PhD in biochemistry or molecular biology is required.Should have at least one first author publication.Moffitt Postdocs are provided with Medical Insurance (Moffitt covers premium for team members) effective upon start date and eligible for Dental, Vision, Paid Time Off, Retirement, Parental Leave, and more. You may be eligible for relocation assistance per policy.If you have the vision, passion, and dedication to contribute to our mission, then we have a place for you.How to Apply : Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Chen at Jiandong.Chen@moffitt.org.Moffitt Cancer Center is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status.
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Location: Tampa, FLDepartment: Molecular OncologySchedule: Full Time - Day Shift - variesAt Moffitt Cancer Center, we strive to be the leader in understanding the complexity of cancer and applying these insights to contribute to the prevention and cure of cancer. Our diverse team of over 9,000 is dedicated to serving our patients and creating a workspace where every individual is recognized and appreciated. For this reason, Moffitt has been recognized on the 2023 Forbes list of America’s Best Large Employers and America’s Best Employers for Women. Additionally, Moffitt is proud to have earned the prestigious Magnet designation in recognition of its nursing excellence.SummaryMolecular Oncology Postdoctoral Fellow in the lab of Dr. Jiandong ChenThe research interest of the lab is to study the structures, regulation, and therapeutic targeting of the p53 tumor suppressor pathway for cancer treatment. Ongoing work involves the development of novel PROTACs, targeting of temperature-sensitive mutant p53, transcription potential of mutant p53, and MDMX regulation of Wnt signaling. Link to publications from Dr. Chen’s lab:The lab has significant expertise and provides mentorship in the areas of p53/MDM2/MDMX phosphorylation signaling, ubiquitination, transcriptional regulation, and drug discovery using biochemical/cellular assays and mouse tumor models.Extensive collaborations with chemists and structural biologists working in drug discovery, providing a rich environment for training and career development.Moffitt integrates excellent patient care with cutting-edge clinical and basic research.Outstanding mentorship from expert faculty with wide-ranging funded research programs including T32 Training Grants.You will be encouraged and supported to apply for training grants.The Ideal Candidate:Strong background in biochemistry and molecular biology.Experience with mouse tumor xenograft models or genetically modified mouse models.Experience in the analysis of novel drug activity and mechanisms.Competent in cell culture, protein analysis, CRISPR, and recombinant DNA techniques.Recent PhD graduate in biochemistry or molecular biology.Responsibilities:Plans and performs experiments directed towards answering specific scientific questions with limited supervision under the general guidance of the Investigator.Interacts closely with the Investigator and other researchers within the Investigator laboratory and conducts relevant background research including literature searches and reviews.Credentials and Qualifications:MD or PhD in biochemistry or molecular biology is required.Should have at least one first author publication.Moffitt Postdocs are provided with Medical Insurance (Moffitt covers premium for team members) effective upon start date and eligible for Dental, Vision, Paid Time Off, Retirement, Parental Leave, and more. You may be eligible for relocation assistance per policy.If you have the vision, passion, and dedication to contribute to our mission, then we have a place for you.How to Apply : Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Chen at Jiandong.Chen@moffitt.org.Moffitt Cancer Center is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status.
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