Alnylam Pharmaceuticals
Senior Associate Scientist, Metabolomics
Alnylam Pharmaceuticals, Cambridge, Massachusetts, us, 02140
This role is considered On-Site.Overview
Alnylam's Research department is seeking a highly motivated Senior Associate Scientist in Metabolomics. We use untargeted and targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolomics/lipidomics to support target discovery and validation efforts (e.g. biomarker identification and pharmacodynamic measurements) for our RNAi-based therapeutics. The successful candidate will have a background in biological sample preparation for small molecules/endogenous metabolites, LC-MS/MS operation, and data analysis. Ideally, the candidate will also have some experience with mammalian cell culture, molecular biology techniques, and computational workflows for handling large omics-level data sets.Responsibilities
Design, validate, and apply LC-MS/MS methods for metabolite/small molecule quantification to identify biomarkers, characterize pharmacodynamic activity, and screen novel drug targets.Perform end-to-end metabolite sample preparation protocols for cultured cells, biofluids, and solid tissues.Conduct wet lab experiments, e.g. cell culture, to support metabolomics workflows.Maintain QC records, analyze data, and document protocols/results in a clearly organized electronic lab notebook.Perform regular maintenance and troubleshoot LC-MS instruments as needed.Communicate results in team meetings.Qualifications
Minimum of Bachelor's degree in chemical engineering, biological engineering, chemistry, biochemistry, biology, or related field required.Master's Degree and/or 3+ years relevant academic or industry experience preferred.Direct experience with LC-MS/MS-based methods for small molecule/metabolite quantification and general analytical biochemistry techniques (e.g. standard curve construction, making buffers) is essential.Familiarity with metabolite extraction/purification from cultured cells, tissues, and/or biofluids is highly desirable.Experience with mammalian cell culture and/or basic molecular biology techniques (e.g. qRT-PCR, Western blots) is desirable.General familiarity with biochemistry/cellular metabolism.Some familiarity with basic programming languages, particularly Python, is a strong plus.Strong written and oral communication skills.Strong abilities to work both independently and in a team environment.Intellectual curiosity, a passion for science, and a willingness to ask questions.About Alnylam:
Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.Our culture:
Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.
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Alnylam's Research department is seeking a highly motivated Senior Associate Scientist in Metabolomics. We use untargeted and targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolomics/lipidomics to support target discovery and validation efforts (e.g. biomarker identification and pharmacodynamic measurements) for our RNAi-based therapeutics. The successful candidate will have a background in biological sample preparation for small molecules/endogenous metabolites, LC-MS/MS operation, and data analysis. Ideally, the candidate will also have some experience with mammalian cell culture, molecular biology techniques, and computational workflows for handling large omics-level data sets.Responsibilities
Design, validate, and apply LC-MS/MS methods for metabolite/small molecule quantification to identify biomarkers, characterize pharmacodynamic activity, and screen novel drug targets.Perform end-to-end metabolite sample preparation protocols for cultured cells, biofluids, and solid tissues.Conduct wet lab experiments, e.g. cell culture, to support metabolomics workflows.Maintain QC records, analyze data, and document protocols/results in a clearly organized electronic lab notebook.Perform regular maintenance and troubleshoot LC-MS instruments as needed.Communicate results in team meetings.Qualifications
Minimum of Bachelor's degree in chemical engineering, biological engineering, chemistry, biochemistry, biology, or related field required.Master's Degree and/or 3+ years relevant academic or industry experience preferred.Direct experience with LC-MS/MS-based methods for small molecule/metabolite quantification and general analytical biochemistry techniques (e.g. standard curve construction, making buffers) is essential.Familiarity with metabolite extraction/purification from cultured cells, tissues, and/or biofluids is highly desirable.Experience with mammalian cell culture and/or basic molecular biology techniques (e.g. qRT-PCR, Western blots) is desirable.General familiarity with biochemistry/cellular metabolism.Some familiarity with basic programming languages, particularly Python, is a strong plus.Strong written and oral communication skills.Strong abilities to work both independently and in a team environment.Intellectual curiosity, a passion for science, and a willingness to ask questions.About Alnylam:
Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.Our culture:
Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.
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