Tentarix
Senior Scientist – Mammalian Expression
Tentarix, San Diego, California, United States, 92189
About the Company:
Tentarix Biotherapeutics is an exciting company with a game-changing technology platform that allows for the discovery of next generation, multi-specific investigational drugs, called
Tentacles , to address limitations of existing cancer, autoimmune and other disease therapies.We are led by a seasoned executive team with proven expertise in the field of multi-specific drug discovery. We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape with our ground-breaking technology.Tentarix team members are creative, hands-on, self-directed, and display excellent communication skills. They also exhibit a high level of integrity, resiliency, and a determination to contribute to the success of the company. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our individuals and collectively.Role:The Senior Scientist Mammalian Expression will lead a San Diego-based Mammalian Expression Team responsible for expression and characterization of Tentacle (multi-specific) molecules. Additionally, the Senior Scientist will collaborate with the other Biologics and Biology Teams to provide protein material, characterization data and molecular biology support to move Tentarix’s project portfolio forward.Responsibilities:Manage a team fully responsible for mammalian expression of Tentarix’s molecules and downstream screening:Coordinate and optimize Tentarix’s transient transfectionsInnovate to optimize our high throughput expression capabilitiesImplement rapid CHO stable cell line system for optimized protein leads and antigensWork with our automated notebook, molecular biology, and workflow software partner to establish the process for improved data capture and lot trackingScreen libraries via common affinity characterization methods such as ELISA, MSD, BLI, and FLOW cytometryInterface closely with project team members to ensure assays and screening efforts are aligned with project goalsInterpret, summarize, and report research findings in team meetings and contribute to research strategy discussionsBuild strong lines of communication with the other teams at Tentarix to ensure proper hand-offs, maintain efficient workflows and to maximize our capabilitiesMaintain a culture of innovation and continual improvementContribute to the development of analytical methods for affinity characterizationCross train team members to ensure consistency and flexibilityTransition current in-house mammalian platform to incorporate proprietary technologies and expanded workflowsQualifications and Skills:Ph.D. in cell biology, molecular biology, or other related scientific fields and 2-4 years industry experience, or MS with 10+ years of experience, BS with 12+ years of experience.Strong background in mammalian cell culture and transient expression with outstanding aseptic techniqueExperience in state-of-the-art molecular biology methods is preferredProficiency with immunoassays; such as ELISA, MSD, and bio-layer interferometry (BLI), and flow cytometry is desiredExperience with biologics including antibody and antibody-like therapeutics, including bispecific antibodies is preferredSome managerial experience leading small teams is preferred with an ability to grow as a leaderGoal oriented, organized, capable of prioritizing across multiple projects, and able to execute to timelines that meet company goalsCommitment to exhibiting the highest levels of integrity, ethics and scientific standardsA track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions.Thrive in a cross functional team environment and committed to positively contributing to Tentarix supportive small company cultureExcellent verbal and written communication skillsConfident, independent and decisive; proactive and results-oriented with high performance standardsHands-on contributor who understands the need for involvement at all levels of activity within a small company environmentOur employees are the Company’s most valuable asset, so we offer attractive compensation and benefits packages to retain the best in the field. Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status.The wage range for this role takes into account the wide range of factors that are considered in making compensation decisions including but not limited to skill sets, experience, training, licensure, certifications, and other business and organizational needs. The disclosed range estimate has not been adjusted for the applicable geographic differential associated with the location at which the position may be filled. A reasonable estimate of the current range is $130,000 – 145,000 + bonus target + benefits + equity.Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. We are an E-Verify employer.
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Tentarix Biotherapeutics is an exciting company with a game-changing technology platform that allows for the discovery of next generation, multi-specific investigational drugs, called
Tentacles , to address limitations of existing cancer, autoimmune and other disease therapies.We are led by a seasoned executive team with proven expertise in the field of multi-specific drug discovery. We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape with our ground-breaking technology.Tentarix team members are creative, hands-on, self-directed, and display excellent communication skills. They also exhibit a high level of integrity, resiliency, and a determination to contribute to the success of the company. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our individuals and collectively.Role:The Senior Scientist Mammalian Expression will lead a San Diego-based Mammalian Expression Team responsible for expression and characterization of Tentacle (multi-specific) molecules. Additionally, the Senior Scientist will collaborate with the other Biologics and Biology Teams to provide protein material, characterization data and molecular biology support to move Tentarix’s project portfolio forward.Responsibilities:Manage a team fully responsible for mammalian expression of Tentarix’s molecules and downstream screening:Coordinate and optimize Tentarix’s transient transfectionsInnovate to optimize our high throughput expression capabilitiesImplement rapid CHO stable cell line system for optimized protein leads and antigensWork with our automated notebook, molecular biology, and workflow software partner to establish the process for improved data capture and lot trackingScreen libraries via common affinity characterization methods such as ELISA, MSD, BLI, and FLOW cytometryInterface closely with project team members to ensure assays and screening efforts are aligned with project goalsInterpret, summarize, and report research findings in team meetings and contribute to research strategy discussionsBuild strong lines of communication with the other teams at Tentarix to ensure proper hand-offs, maintain efficient workflows and to maximize our capabilitiesMaintain a culture of innovation and continual improvementContribute to the development of analytical methods for affinity characterizationCross train team members to ensure consistency and flexibilityTransition current in-house mammalian platform to incorporate proprietary technologies and expanded workflowsQualifications and Skills:Ph.D. in cell biology, molecular biology, or other related scientific fields and 2-4 years industry experience, or MS with 10+ years of experience, BS with 12+ years of experience.Strong background in mammalian cell culture and transient expression with outstanding aseptic techniqueExperience in state-of-the-art molecular biology methods is preferredProficiency with immunoassays; such as ELISA, MSD, and bio-layer interferometry (BLI), and flow cytometry is desiredExperience with biologics including antibody and antibody-like therapeutics, including bispecific antibodies is preferredSome managerial experience leading small teams is preferred with an ability to grow as a leaderGoal oriented, organized, capable of prioritizing across multiple projects, and able to execute to timelines that meet company goalsCommitment to exhibiting the highest levels of integrity, ethics and scientific standardsA track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions.Thrive in a cross functional team environment and committed to positively contributing to Tentarix supportive small company cultureExcellent verbal and written communication skillsConfident, independent and decisive; proactive and results-oriented with high performance standardsHands-on contributor who understands the need for involvement at all levels of activity within a small company environmentOur employees are the Company’s most valuable asset, so we offer attractive compensation and benefits packages to retain the best in the field. Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status.The wage range for this role takes into account the wide range of factors that are considered in making compensation decisions including but not limited to skill sets, experience, training, licensure, certifications, and other business and organizational needs. The disclosed range estimate has not been adjusted for the applicable geographic differential associated with the location at which the position may be filled. A reasonable estimate of the current range is $130,000 – 145,000 + bonus target + benefits + equity.Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. We are an E-Verify employer.
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