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University of California

STAFF001413 Staff Research Associate I

University of California, San Francisco, California, United States, 94199


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STAFF001413 Staff Research Associate ISTAFF001413 Staff Research Associate I

Location :4150 Clement St

#151NC

San Francisco ,

CA

94121

United StatesJob Posted Date :November 9, 2023Full-time PositionsPopulation :OtherNorthern California Institute for Research and Education (NCIRE) is the leading nonprofit research institute in the United States devoted to advancing Veterans health research. NCIRE is part of one of the world’s most dedicated and successful Veterans care communities, pioneering new treatments and understandings of military medicine and care.Make your Impact on SocietyAre you looking to make a profound difference? Join a culture of revolutionary research that is looking to eradicate HIV. A full-time Staff Research Associate I position is immediately available for a highly motivated individual wanting to apply for training in the biological sciences and virology to study the barriers to curing HIV. This position is funded and hired through the Northern California Institute for Research and Education (NCIRE) - The Veterans Health Research Institute, which is affiliated with the San Francisco VA Medical Center (SFVAMC) and the University of California, San Francisco (UCSF). UCSF is a world leader in HIV/AIDS research and treatment. The incumbent will be working within the laboratory of UCSF Principal Investigator, Prof. Steven Yukl, on the campus of the San Francisco VA Medical Center.The Yukl laboratory performs basic and translational research focused on understanding the barriers to curing HIV, with an emphasis on investigating the mechanisms that allow HIV-infected cells to persist in the blood and tissues. Research areas include:Mechanisms that govern latent HIV infection/reactivation and the regulation of HIV transcription;Cellular factors involved in HIV latency and HIV expression;Differences between blood and tissues in the types of HIV reservoirs, their mechanisms of persistence, and their responses to therapies aimed at curing HIV;Contribution of HIV-expressing cells to immune activation/inflammation and viral rebound after interruption of antiretroviral therapy;Development and testing of new therapies to disrupt latent HIV infection (latency reversing agents, latency promoting agents) or induce selective killing of HIV-infected cells;Development of new assays to quantify HIV reservoirs and investigate mechanisms of HIV latency/persistenceIn addition, we have projects aimed at understanding the transcriptional regulation and pathogenesis of SARS-CoV-2, the etiologic agent of COVID-19. These projects involve the implementation and development of laboratory assays to apply to samples from infected and uninfected individuals, as well as cell lines and primary cells infected in vitro. We also pursue collaborative mechanistic studies with other investigators throughout the San Francisco Bay Area, the United States, and many other countries.Training will be provided to enable the candidate to engage in multiple different laboratory projects. In addition to training in laboratory techniques, candidates will be provided with opportunities to present their research at local, national, and international meetings, and to write manuscripts.Essential Functions:Provide services supportive to the mission of the laboratory, including ordering and maintaining supplies, assisting with compliance and lab safety protocolsDesign and execute experiments using cellular, biochemical, and molecular biology techniques, including DNA and RNA extraction, PCR, real time PCR, droplet digital PCR, and other techniquesProcess human biological samples, including isolation of cells from blood and tissues; store and ship samplesPerform in vitro HIV infection and propagation experimentsMaintain detailed written record of work performedPerform analysis of experiment results and findings, including data collection, entry, and graph creationProduce written reports detailing results of experiments and analysis of resultsAdhere to data security requirementsPerform other duties as assignedJob Requirements:Knowledge of principles and practice of cellular and molecular biologyRelated work experience (laboratory-based research) desirableWorking knowledge of safety standards in laboratoriesExcellent organizational skillsCareful attention to detail; ability to accurately follow experimental protocolsAbility to manage multiple projects, tasks, and priorities to achieve desired goalsAbility to think creatively, solve problems, and meet deadlinesAbility to work independently and as part of a teamStrong organizational, interpersonal, and written/oral communication skillsComputer literacy with full working knowledge of MS Word and ExcelFamiliar with basic data analysis techniquesAbility to make sound decisions in a manner consistent with the essential job functionsThe San Francisco Bay Area is globally known as a leader in biomedical research and innovation. This area has an ingrained culture of collaboration and economic and civic vitality. The research environment will include employees from NCIRE, UCSF, and the SFVAMC, which are all known for supporting and administering cutting edge, outstanding research with HIV.By joining us, you join not only our mission but scientific movement.The base salary range for this position is $24.11-$28.87 per hour. The base salary actually offered to a successful candidate will take into account various relevant and non-discriminatory business factors including, without limitation, the candidate’s geographic location, job-related experience, knowledge, and skills, and education, as well as internal equity considerations. A successful candidate may also be eligible to earn additional compensation including bonuses.Or apply by visiting us at www.ncire.org

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STAFF001413 Staff Research Associate I .Northern California Institute for Research and Education (NCIRE) is proud to be an Equal Opportunity Employer.Per San Francisco's Fair Chance Ordinance, Northern California Institute for Research and Education (NCIRE) will consider qualified applicants with criminal histories.

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